Hyperthermia was first demonstrated to restore cell death induced by TNFα in the late 80s.33, 34 Only recently has hyperthermia been successfully exploited in the clinic with TNFα to treat limb soft tissue sarcomas with high response rates,35 or locally advanced cancers.36 Besides TNFα, hyperthermia can also promote Fas ligand and TRAIL-induced apoptosis.25, 37, 38 Accordingly, we show here that hyperthermia restores TRAIL pro-apoptotic signaling in a large panel of tumor cell lines. This evidence concerns the gene TNF and cancer.