CFLAR and neoplasm: Hyperthermia is known to induce protein aggregation, leading eventually to cell death.48, 49 In agreement with these findings, not only the disappearance of c-FLIP but also, to a lesser extent, of initiator caspases including caspase-8 and caspase-10 from the non-ionic detergent soluble fraction after hyperthermia was detected in all the tumor cell lines studied.