Hyperthermia restores TRAIL-induced apoptosis in tumor cells17, 23, 24 but not in normal cells.25 In line with these findings, incubating resistant cancer cell lines of various origin for 1 h at 42 °C (HS) in the presence of TRAIL followed by subsequent incubation at 37 °C for 5 h (Figure 1a), significantly increased apoptosis triggered by TRAIL as compared with a 6 h incubation time at 37 °C (Figure 1b). This evidence concerns the gene TNFSF10 and cancer.