These results are supported with previous studies that demonstrated the anti-inflammatory effect of genistein and 17β-estradiol in Alzheimer’s disease through decreasing COX-2 and iNOS expression in cultured astrocytes [81] and the effect of genistein in inhibiting hemolysate-induced iNOS and COX-2 expression in primary astrocytes [82]. Here, PTGS2 is linked to early-onset autosomal dominant Alzheimer disease.