miR-22 can regulate the PTEN/AKT pathway and target HDAC6 [66–68]; miR-206 and miR-1a can suppress hepatic lipogenesis [69]; miR-29b and miR-9 are involved in insulin sensitivity and diabetes [70,71]; miR-31 and miR-32 participate in differentiation of stem cells into adipocyte and lipid metabolism in oligodendrocytes [72,73]. This evidence concerns the gene HDAC6 and diabetes mellitus.