EGFR has been implicated in regulating growth and survival of NSCLC, with overexpression occurring in 45% to 70% of the cases, which is also accompanied by a constitutive activation of the major downstream EGFR effector proteins including PI3K [6], AKT [7], ERK [8], and STAT3 [9]. Here, MAPK1 is linked to non-small cell lung carcinoma.