VEGFA and neoplasm: Similar results were observed in other studies.8,35 However, some studies demonstrated a significant increase in the ADC at the end of the first week.36,37 Sun et al demonstrated that vascular endothelial growth factor, which could lead to increased vascular permeability and increased interstitial volume, had a massive release within 1 week after beginning CRT, thereby causing tumor edema and increasing the ADC.36