However, the whole tumor always includes areas of necrosis and mucin pools, which could cause an increase in the ADC value and lead to an overestimation of the therapeutic effects.8 Other factors, such as variations in the study design, patient characteristics, different parameters of MRI, and the individual differences of radiologists, surgeons, and pathologists, also contributed to the heterogeneity. This evidence concerns the gene MUC5AC and neoplasm.