As also indicated by other studies, NT-proBNP was more affected than BNP by the decline in renal function, probably due to its exclusive renal clearance.3 Dialytic treatment with LF or HF membranes affects differently the removal of natriuretic peptides both in pre-dialysis concentrations and even more in post-dialysis plasma values.37–39 In fact, only HF membranes can remove BNP and NT-proBNP from plasma. The gene discussed is NPPB; the disease is hydrops fetalis.