Nonetheless, it should be noted that in Northern and Eastern European (Vahteristo et al. 2002; CHEK2 Breast Cancer Case–control Consortium CHEK2*1100delC and susceptibility to breast cancer 2004; Meijers-Heijboer et al. 2002) CHEK2 1100delC mutation is associated with an increased risk of Breast Cancer (on the basis of age at diagnosis and family history of breast cancer). This evidence concerns the gene CHEK2 and breast cancer.