VEGFA and diabetic macular edema: Up to 10% of all patients with diabetes will develop diabetic macular edema (DME) during their lifetime.2 Vascular endothelial growth factor (VEGF) has been shown to be a critical stimulus in the pathogenesis of macular edema secondary to diabetes.3 Diabetic macular edema commonly leads to visual loss in patients with diabetes mellitus and this loss of vision can be irreversible.4 Increase in vascular permeability due to diabetes results in leakage of fluid and plasma constituents into the retina leading to DME.