CYP1B1 and primary congenital glaucoma: CYP1B1 is the major contributor to primary congenital glaucoma in various ethnic groups.11-13 It is highly associated in inbred populations which includes, Slovakian Gypsies14 Turkish15 and Saudi Arabians.16,17 Previously, mutations in CYP1B1 were identified in three out of thirteen or 23% Pakistani consanguineous families.