This is in accordance with a recent report, which identified maternal age, elevated BMI, elevated DBP and family history of diabetes mellitus as significant risk factors for GDM.17 Also another study determined advanced maternal age, pre-pregnancy overweight or obesity and family history of diabetes as specific risk factors for GDM.4 We assessed the insulin metabolism unlike some other authors, which used the Insulin Secretion-Sensitivity Index (ISSI)18,19 by IFI and found that GDM and GIGT were gradually associated with impaired insulin secretion. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.