Recently, mutations in the 5′UTR region of ENG (c.-9G > A and c.-127C > T) were also shown to cause HHT in several patients, indicating the need for the inclusion of the ENG 5′UTR region in routine molecular diagnostic testing for HHT (Damjanovich et al., 2011). The gene discussed is ENG; the disease is hereditary hemorrhagic telangiectasia.