Moreover, CD27 signals induced calcium fluxes and upregulated the expression of Cyclin D2 and the anti-apoptotic gene Bcl2a1. Given the typical IFN-γ secretion and cytotoxicity of activated Vγ9Vδ2 T-cells (30), our work suggests that the modulation of CD70–CD27 signals may be beneficial in the context of γδ T-cell-based cancer immunotherapy. This evidence concerns the gene CD27 and cancer.