In another immunization treatment with monocyte-derived DC incubated with preheated autologous tumor lysate and subsequently with IFN-γ, TNF-α, and polyinosinic:polycytidylic acid to attain type 1 maturation, treatment induced sustained, elevated IL-12 serum levels that correlated with the IL-12p70 output of cultured DC from each individual. Here, TNF is linked to neoplasm.