While cholinomimetic drugs such as acetylcholinesterase (AChE) inhibitors, which elevate extracellular levels of the neurotransmitter acetylcholine (ACh), are the viable treatment option for AD and provide moderate alleviation to cognitive impairment, the magnitude of cognitive improvements with these drugs has remained limited (McGleenon et al., 1999; Raina et al., 2008). Here, ACHE is linked to Alzheimer disease.