To the best of our knowledge, the present study is the first to demonstrate the differential expression of S100A8/A9 and their associated genes among patients with RCC, benign renal mass, normal kidney and other types of urological malignant tumor at a serum and tissue level and is also the first to confirm the differential expression among the different types of cancer cell populations through transplatform bioinformatics analysis. This evidence concerns the gene S100A8 and cancer.