To the best of our knowledge, the present study is the first to demonstrate the differential expression of S100A8/A9 and their associated genes among patients with RCC, benign renal mass, normal kidney and other types of urological malignant tumor at a serum and tissue level and is also the first to confirm the differential expression among the different types of cancer cell populations through transplatform bioinformatics analysis. Here, IGKV1D-22 is linked to renal cell carcinoma.