MCL1 and acute myeloid leukemia: In addition, studies conducted in acute myeloid leukaemia (AML) cells, the anti-apoptotic activity of the BCL2-associated athanogene-1 (BAG1) was suggested to occur via USP9X and MCL1; BAG1 was found to immunoprecipitate with both USP9X and MCL1, and reduced BAG1 expression resulted in the depletion of both and associated with elevated MCL1 ubiquitylation [60].