An in vitro experiment showed that incubation of 3T3-L1 adipocytes with insulin results in a significant decrease in the miR-183-5p level (51); miR-183-5p can inhibit apoptosis in human hepatocellular carcinoma cells (52) and was found upregulated in cirrhotic liver and premalignant lesions (53). Here, INS is linked to hepatocellular carcinoma.