Consistent with these results, it was previously demonstrated that prolonged exposure to the cAMP-responding element-binding (CREB) protein and c-Ets1 (LABA) contribute to mucous cell hyper-secretion associated with common respiratory disorders (20), suggesting a role for the β2AR-cAMP-CREBs signaling pathway in this process. The gene discussed is ETS1; the disease is respiratory system disorder.