Furthermore, a study by Chen et al (15) has revealed that Tan IIA effectively inhibits the release of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, in a rat model of cerebral ischemia/reperfusion injury (15), suggesting that Tan IIA possesses anti-inflammatory potential. Here, TNF is linked to Cerebral ischemia.