In light of these findings, we aimed to appraise (1) whether the hOGG1 1245 GG genotype contributes to a higher rate of SLE development and higher plasma level of 8-OHdG; (2) whether the hOGG1 1245 GG genotype confers a higher incidence to the development of nephritis in SLE patients; and (3) whether the hOGG1 1245 GG genotype modulates the plasma level of 8-OHdG in SLE patients with or without nephritis. Here, OGG1 is linked to systemic lupus erythematosus.