OGG1 and neurodegenerative disease: This discrepancy in hOGG1 repair activity implies that hOGG1 1245 GG genotype with lower efficiency in DNA repair might be related to a higher level of 8-OHdG in human tissues [10], and may contribute to the development of several human degenerative diseases, including type 2 diabetes mellitus [11], Huntington’s disease [12], chronic obstructive pulmonary disease [13], Graves’ ophthalmopathy [14], and higher susceptibility to cancer formation, including lung cancer [15] and esophageal squamous cell carcinoma [16].