G6PD and G6PD deficiency: In particular, in the West African setting, the frequency of the 202A allele is often substantially lower than rates of enzyme deficiency indicating a role for other alleles; inclusion of other G6PD polymorphisms (Santamaria 542T/376G—∼2% residual enzymatic activity, Betica-Selma 968C/376G—∼11% activity)[10, 16] was required to capture an association between G6PD deficiency and severe malaria in The Gambia [8].