BTNL2 and inflammatory bowel disease: Although no variants other than the two rare and highly correlated missense mutations in BTNL2 surpassed the Bonferroni threshold for testing the 79 independent variants for association with IBD, there was significant enrichment for association signals among these 79 variants, and our extension study and combined analysis showed that the direction of the effect for all 5 SNVs tested was consistent with the initial finding.