NRF1 and neuroblastoma: Miglio et al. earlier showed that low concentrations of PIO and ROSI (maximal effect at ~100 nM) induced expression of mitochondrial transcription factors (NRF1 and TFAM), the transcription co-activator PGC-1α, PPARγ itself, electron transport chain components (cytochrome c oxidase subunits I and IV), and mitochondrial DNA content in cultured neuroblastoma cells, and protected the cells against glucose deprivation-induced cell death [5].