To reveal whether fad104 is negatively correlated with tumor progression in other melanoma cell lines, we investigated the role of fad104 on invasion of A2058 melanoma cells, which have a highly metastatic potential, by transfecting siRNAs targeting fad104. Both sifad104-A and sifad104-B partially suppressed the expression of endogenous FAD104 (Fig. 4A). The gene discussed is FNDC3B; the disease is melanoma.