IPA analysis of both EZH2 inhibitor-treated IGR1 cells and A375 EZH2 Y641F cells also revealed EZH2-dependent regulation of genes involved in axonal guidance (as well as Ephrin receptor signaling), suggesting that the A375 GOF-expressing cells recapitulate endogenous functions of EZH2 GOF mutations in melanoma. The gene discussed is EZH2; the disease is melanoma.