The bodyweight of FIR+/−TP53−/− mice was less than that of FIR+/+TP53−/− mice, and overall survival was reduced in FIR+/−TP53−/− compared with that in FIR+/+TP53−/− mice, presumably due to the rapid progression of T-ALL (Figure 4). The gene discussed is TP53; the disease is acute lymphoblastic leukemia.