The incidence of T-ALL with > 10% bone marrow infiltration of blast cells was higher in FIR+/−TP53−/− mice (5 of 23; 21.7%, including three live mice before analysis) compared with that in FIR+/+TP53−/− (1 of 19; 5.3%, including two live mice before analysis) (Figures 4E, F). The gene discussed is TP53; the disease is acute lymphoblastic leukemia.