NOTCH1 and thymus lymphoma: In contrast, analysis of CD4low+CD8+ thymic lymphoma cells demonstrated that the focal adhesion pathway (Figure S4B) was activated more significantly in FIR+/−TP53−/− (A605) than in FIR+/+TP53−/− (D619) mice. The upregulation of c-myc and notch1 mRNA was confirmed by qRT-PCR (Table S4, Figure S3C–E).