Validation of GEP results was obtained by real-time PCR analysis, confirming the up-regulation of CDKN1A and down-regulation of MYC, IRAK4, MYD88, STAT3, and, in the ABC-DLBCL cell line, also of IRAK1 (Supplementary Figure 3). This evidence concerns the gene IRAK4 and diffuse large B-cell lymphoma.