TBX21 and neoplasm: Type-1 CD4+ helperT-cells (TH1 cells) polarize from naïve T-cells upon stimulationby interleukin (IL)-12 and upregulation of T-box 21 (TBX21) andmediate CTL proliferation and activation, tumor-rejecting immunity, cellular immuneresponses, and acute inflammation by secreting IL-2, IFN-γ, and tumornecrosis factor (TNF) [13, 14].