In different proteinopathies, the possibility exists that the modified, misfolded, and aggregated proteins associated with each particular disorder (MBP, MOG, SOD1, Aβ, tau, or α-syn) are not adequately degraded or eliminated, and eventually drain with inflammatory mediators to peripheral lymphoid tissues, wherein they are preferentially processed and presented by APCs. The gene discussed is MBP; the disease is proteostasis deficiencies.