Aggregation propensity of a protein is related to the ability of a structure to self-organize, such as mRNA stress granules or paired helical filaments including abundant tau protein in tauopathies, but such structure formation may involve a number of other protein and non-protein factors that have roles in templating and supporting extensive aggregation, often because they harbor intrinsically disordered regions with exceptional, if not also conditional, aggregation propensity [95] that can be modulated by PTMs such as phosphorylation [96]. The gene discussed is MAPT; the disease is tauopathy.