CLCN5 and Dent disease: There is genetic heterogeneity for Dent disease, with approximately 60% of patients having CLCN5 mutations (Dent disease 1), ~15% harboring OCRL1 mutations (Dent disease 2) and the remaining 25% of patients having neither CLCN5 nor OCRL1 mutations but possibly defects in other genes [21].