BMI1 and Epstein-Barr virus infection: Furthermore, knockdown of NRP1 led to a significantly decreased EBV infection in EGF-treated HNE1 and NPEC1-Bmi1 cells maintained in KSF medium supplemented with EGF (Fig. 2h,i and Supplementary Fig. 9), suggesting that EGF-induced uptake of EBV at least partially depended on the induction of NRP1.