In other cases, particularly in PS patients with IgE directed to the major peanut allergens (eg, Ara h 1, Ara h 2, and Ara h 3), which is known to be able to elicit effector cell activation and degranulation18,19 and would otherwise be a strong predictor of peanut allergy, inhibition of IgE by blocking antibodies might explain in part the absence of allergic symptoms after peanut ingestion. The gene discussed is IGHE; the disease is peanut allergic reaction.