AR and posterior cortical atrophy: Given that PPARγ has also been shown to play a role in prostate development and maintenance [26], and PPARγ agonists such as troglitazone have been demonstrated to inhibit AR expression and PCa cell growth in vitro and in vivo [27–29], we reasoned that PPARγ modulation may be an unanticipated activity of EPI-001 in PCa cells.