Our findings that EPI-001-mediated inhibition of AR activity is associated with inhibition of AR expression and activation of PPARγ in PCa, coupled with the finding that EPI-001 can capture nucleophilic thiols, will be important for ongoing pre-clinical development of EPI-001 and other anti-AR compounds that target functional domains independent of the AR LBD. This evidence concerns the gene PPARG and posterior cortical atrophy.