PPARG and posterior cortical atrophy: SPPARM activity for EPI-001 is consistent with studies demonstrating that the chemically-related compound, BADGE, is a SPPARM that binds to the PPARγ LBD [23] and exhibits distinct molecular effects in PCa and 3T3-L1 cells when compared with synthetic thiazolidinedione PPARγ agonists [23–25] including troglitazone [36–38].