Eighteen of the 40 UK patients with RCC received Nap (15 μg/kg given intravenously in three cycles of four once-daily injections) plus IFN-α (9 MU subcutaneously three times weekly) and 22 UK patients received the same dose and schedule of IFN-α monotherapy except for weeks with Nap treatment. The gene discussed is IFNA1; the disease is renal cell carcinoma.