Using Ingenuity Pathway Analysis, low DMC score MMCs showed an enrichment for pathways of the DMC system including LXR, PXR, FXR, Cytochrome P450 pathways, together with an enrichment for cytokine pathways (hyper cytokinemia, hyper chemiohinema and atherosclerosis signaling pathways) with TREM1, STAT3, Rel A, CREB and ILβ as upstream regulators (Figure 6A). The gene discussed is CREB1; the disease is atherosclerosis.