JUN and cancer: Ultimately, the blockade of c-Myc mRNA transport by the tylophorine-mediated sequester of the caprin-1, G3BP1, c-Myc mRNA, and cyclin D2 mRNA-containing RNP complex may contribute significantly to the anti-cancer effects elicited by tylophorine in conjunction with the accumulation of c-Jun [25] (Fig. 7).