CCND1 and carcinoma: Significantly, pull-down experiments using biotinylated tylophorine revealed the association of caprin-1, G3BP1, c-Myc mRNA, and cyclins D1/D2 mRNA in untreated carcinoma cell lysates (Fig. 1D and 2B) in which the mRNAs for c-Myc and cyclin D1 and D2 were not upregulated, as was observed in the tylophorine-treated carcinoma cells (Fig. 2D-a).