However, most of the other genes associated with PDL1 upregulation were genes directly involved in T-cells activation (ZAP70, ITK, LCK, JAK3,...), differentiation factors (EOMES, STAT1, STAT4, CD27...), cytotoxic effector molecules (GZMA, GZMB, GZMK, PRF1, GNLY, C1QA...), inflammation/anti-tumor cytokines (IL2RG, IL2RB, IL21R, IL27R, IL15, IL18BP, LTB, some interferon-induced proteins...), and chemokines related to T-cells activation and homing (CCL2, CCL4, CCL5, CCL8, CCL18, CXCL1, CXCL9-11, CCR5,...). This evidence concerns the gene PRF1 and neoplasm.