Altogether, these observations suggested that the biological link between PDL1 upregulation and activated T-lymphocyte infiltrate might be related to IFNγ or other inflammatory cytokines, secreted by anti-tumor TH1-cells or macrophages, which can positively regulate PDL1 expression, notably in basal tumor cells [37] in response to immune-mediated attack [19], in order to decrease the cytotoxic local immune response. This evidence concerns the gene IFNG and neoplasm.