TFAP2A and nasopharyngeal carcinoma: The results showed that knockdown of AP-2α expression by AP-2α siRNA (si-AP2, 100 nM) for 72 hours significantly inhibited cell viability when compared with the transfection with the non-specific siRNA (si-NS, 100 nM) and mock control groups, resulting in a 20% to 30% inhibitions in cell viability in the four kinds of NPC cell lines (Fig. 3A).