NFKB1 and nasopharyngeal carcinoma: To determine whether these effects were responsible for AP-2α-mediated control of COX-2, transient transfection experiments were performed with a series of COX-2 promoter reporter constructs in which the binding sites for NF-κB and/or AP-2 nuclear protein were deleted and the plasmids of AP-2α or the siRNA of AP-2α in NPC cell.