Given the high affinity binding of Wnt ligands to HS [23] and the link between altered HSPGs, heparanase, and tumor cell metastasis [24-26], investigating HS mimetics/heparanase inhibitors effect on Wnt signaling was considered a novel approach to discover new therapeutic options for pancreatic carcinomas. This evidence concerns the gene HPSE and exocrine pancreatic carcinoma.