PG545 interacts with Wnt3a and Wnt7a to preventing them from binding to their receptors, LRP5/6 and Frizzled (Fig. 2), resulting in significantly decreased β-catenin levels (Fig. 1), suppressed tumor growth and metastasis in pancreatic tumors (Fig. 5). This evidence concerns the gene WNT7A and pancreatic neoplasm.