FBXW7 and neoplasm: In fact, in human T-cell acute lymphoblastic leukemia (T-ALL), FBXW7 is one of the most frequently mutated genes (approximately 30% of cases [45]) and mouse models with tissue specific knockout of FBXW7 in various settings develop both hematopoietic and solid tumors [46], corroborating the tumor suppressing functions of FBXW7 in these contexts.