On the contrary, increased peritumoral FOXP3+T-cell counts showed a significant association with worse outcome and were found to be an independent prognostic factor in the multivariate analysis, when adjusted for T-, N-, M-stage, tumor budding and therapy (p = 0.0027, Table 4, Figure 4) and when adjusted for the other immune cell counts (Suppl. This evidence concerns the gene FOXP3 and neoplasm.