FOXP3 and neoplasm: Increased peritumoral FOXP3+T-cell-counts (FOXP3p) correlated with high-grade tumor budding including budding 10-in-10 (p = 0.0425) previously assessed in whole tissue sections, as well as ITB (p = 0.0428) and PTB (p < 0.0001), assessed at the TMA spots for each protein and showed significant correlation with the presence of venous invasion (p = 0.0189), distant metastasis (p = 0.0073) and positive resection margins (p = 0.0067) (Table 2).