In the linear regression association analysis between these SNPs and CCT, the C allele of SNP rs2521206 in COL1A2 and the T allele of SNP rs7500824 in the ZNF469 region were both weakly associated with a thinner central cornea in the study population after adjusting for age, gender and diagnosis (POAG or control) (Supplementary Table 2). The gene discussed is COL1A2; the disease is open-angle glaucoma.