Additionally, upon examination of primary tumor samples from the cohort described herein, intratumoral T-cells were dominated by the expression of the transcription factor RORγT+, a marker for TH17 cells; however, this preponderance of RORγT+ T-cells within tumors was found in both CEA responders and nonresponders (Supplementary Figure 3, available online). This evidence concerns the gene CEACAM5 and neoplasm.