They also had significantly higher serum MG (p < 0.01), serum CML (p < 0.01), fasting insulin (p < 0.0001) adiponectin (p < 0.01), leptin (p < 0.01), 8-Isoprostane (p < 0.01), white body fat (p < 0.0002) and body weight (p < 0.05; table 1) indicating that dMG+ mice became insulin resistance, a complication that has been observed previously in aged mice on dMG+ diet or standard diet which is also high in AGEs [43]. This evidence concerns the gene INS and Insulin resistance.