In the example of sesame seed that has been reported to negatively interfere with the tumor-inhibitory effect of Tamoxifen [7], the protein responsible for the therapeutic effect of Tamoxifen is the estrogen receptor (P03372), which is also targeted by a number of different bioactive phytochemicals present in sesame, including beta-sitosterol [15][16]. The gene discussed is ESR1; the disease is neoplasm.