ESR1 and musculoskeletal system disorder: Lastly, resveratrol, a compound that earned its prophylactic reputation against cardiovascular diseases due to its presence in red wine (represented by grape in Fig. 3), was found in our analysis to interfere with the activity of several drugs (Diclofenac, Raloxifene, etc.)that target either the estrogen receptor or prostaglandin G/H synthase 2 (involved in musculoskeletal diseases).