However, two otherstudies reported that this SNP showed no correlation with jaw osteonecrosis in patientssuffering from prostate cancer and neither research group could confirm a significantassociation between polymorphisms in the CYP2C8 gene and the risk ofdeveloping osteonecrosis of the jaw in patients with MM receiving treatment with BP inan independent series [51,52]. The gene discussed is CYP2C8; the disease is Miyoshi myopathy.