Examination of TricR497X/R497X mice, which lack tricellulin at TCs at P16, revealed that cochlear hair cell degeneration was more pronounced in the mid and basal turns compared with the apical turn [16], suggesting that the reticular lamina of the organ of Corti in the mid and basal turn is more sensitive to various types of continually varying mechanical stressors in the disrupted tTJ, thereby giving rise to a ski-slope type of partial deafness. Here, MARVELD2 is linked to deafness.