Secernin-1 is described as being deregulated in different carcinomas: secernin-1 is upregulated in colon cancer [71–73], in gastric cancer [73], and in Barrett's esophagus associated with high-grade dysplasia compared to nondysplastic Barrett's esophagus [74]. The gene discussed is SCRN1; the disease is esophageal adenocarcinoma.