S100B and melanoma: For this, a literature search using the search engine “Pubmed” was conducted with the following keywords and phrases: melanoma, malignant melanoma, metastatic melanoma, biomarker, serum/tissue biomarker in melanoma, melanoma therapy, melanoma immunotherapy, targeted therapy in melanoma, S100 melanoma, lactate dehydrogenase (LDH) melanoma, Braf melanoma, and diagnostic markers.